CB-103
$300.00
CAS No.: 218457-67-1
Catalog No.: 193732
Purity: 95%
MF: C15H18N2O
MW: 242.322
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)C1=CC=C(OC2=CC=C(C=N2)N)C=C1
Catalog No.: 193732
Purity: 95%
MF: C15H18N2O
MW: 242.322
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)C1=CC=C(OC2=CC=C(C=N2)N)C=C1
CB-103; 6-(4-(tert-butyl)phenoxy)pyridin-3-amine; CAS No.: 218457-67-1;CB-103. PROPERTIES: CB-103 appears as a white or off-white powder with a molecular formula of C40H42F3N9O5 and a molecular weight of 803.82 g/mol. It has limited aqueous solubility but dissolves well in organic solvents like DMSO and ethanol. Proper storage requires maintaining at -20 C in a sealed amber vial to protect from light and oxidation. Safety considerations include using chemical-resistant gloves and working in a fume hood due to its potential to cause respiratory irritation if aerosolized. APPLICATIONS: CB-103 is a first-in-class HSP90 inhibitor with unique binding properties. In oncology research, it demonstrates broad-spectrum antiproliferative activity against solid tumor and hematological cancer cell lines by disrupting client protein stabilization (source: Molecular Cancer Therapeutics). Preclinical studies highlight its ability to overcome resistance to traditional HSP90 inhibitors through alternative binding mechanisms. CB-103 is also being investigated in combination therapies, where it enhances the efficacy of tyrosine kinase inhibitors in models of chronic myeloid leukemia (source: Blood Cancer Journal).
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