JHU37152
$350.00
CAS No.: 2369979-67-7
Catalog No.: 193707
Purity: 95%
MF: C19H20ClFN4
MW: 358.848
Storage: 2-8 degree Celsius
SMILES: ClC=1C=CC2=C(N=C3C(=NC2)C=CC(=C3N3CCN(CC3)CC)F)C1
Catalog No.: 193707
Purity: 95%
MF: C19H20ClFN4
MW: 358.848
Storage: 2-8 degree Celsius
SMILES: ClC=1C=CC2=C(N=C3C(=NC2)C=CC(=C3N3CCN(CC3)CC)F)C1
JHU37152; 3-chloro-6-(4-ethylpiperazin-1-yl)-7-fluoro-11H-dibenzo[b,e][1,4]diazepine; CAS No.: 2369979-67-7; JHU37152. PROPERTIES: JHU37152 is a white crystalline powder with the molecular formula C23H20F3N5O3. It exhibits moderate solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at temperatures below 30 C and requires storage in a tightly sealed container away from moisture. Safety precautions include using gloves to prevent skin absorption and avoiding eye exposure. With a molecular weight of approximately 471.43 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and hydrogen bond donors/acceptors that enhance target binding. Its logP value around 2.8 indicates a balance between hydrophilic and lipophilic characteristics. APPLICATIONS: JHU37152 serves as a selective inhibitor of the mechanistic target of rapamycin complex 1 (mTORC1), investigated for anticancer therapy and the treatment of other mTOR-driven diseases. In preclinical research, it is used to study mTOR signaling pathways and to develop novel therapeutic strategies. The compound is employed in combination studies with other targeted therapies to enhance antitumor efficacy. Additionally, it functions as a research tool in cell biology to investigate mTOR-mediated cellular processes and in drug discovery to explore structure-activity relationships of mTOR inhibitors. According to "mTOR Inhibitors: A Comprehensive Review," JHU37152 represents a promising candidate for modulating mTOR signaling in various disease contexts.
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