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Physostigmine Salicylate; (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate 2-hydroxybenzoate; CAS No.: 57-64-7;Physostigmine Salicylate. PROPERTIES: Physostigmine Salicylate is a white to off-white crystalline powder with a molecular formula of C30H33N2O7 and a molecular weight of 527.59 g/mol. It has limited aqueous solubility but dissolves in alcohol. Storage should be at room temperature in a tightly sealed container protected from moisture. When handling, avoid skin contact and ingestion due to its potential to cause cholinergic effects. APPLICATIONS: Physostigmine is a reversible acetylcholinesterase inhibitor. In neurology, it's historically used for treating glaucoma by increasing aqueous humor outflow (source: Survey of Ophthalmology). The salicylate ester form enhances its topical ocular bioavailability. Additionally, Physostigmine Salicylate serves as a research tool for studying cholinergic transmission and Alzheimer's disease mechanisms by modulating acetylcholine levels in preclinical models (source: Neuropharmacology).