Orludodstat (BAY 2402234)
$300.00
CAS No.: 2225819-06-5
Catalog No.: 193660
Purity: 95%
MF: C21H18ClF5N4O4
MW: 520.842
Storage: 2-8 degree Celsius
SMILES: ClC1=C(C(=CC=C1)F)NC(C1=C(C=C(C(=C1)F)N1N=C(N(C1=O)CC)CO)O[C@H](C(F)(F)F)C)=O
Catalog No.: 193660
Purity: 95%
MF: C21H18ClF5N4O4
MW: 520.842
Storage: 2-8 degree Celsius
SMILES: ClC1=C(C(=CC=C1)F)NC(C1=C(C=C(C(=C1)F)N1N=C(N(C1=O)CC)CO)O[C@H](C(F)(F)F)C)=O
Orludodstat (BAY 2402234); (S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide; CAS No.: 2225819-06-5; Orludodstat (BAY 2402234). PROPERTIES: Orludodstat (BAY 2402234) is a white to off-white solid with the molecular formula C24H23F3N4O4. It exhibits good solubility in acidic aqueous solutions and moderate solubility in organic solvents like methanol. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety considerations include using gloves to prevent skin contact and avoiding eye exposure. With a molecular weight of approximately 510.47 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms that enhance its binding affinity and metabolic resistance. Its logP value around 2.6 indicates a balance between hydrophilic and lipophilic characteristics. APPLICATIONS: Orludodstat (BAY 2402234) functions as a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH), investigated for the treatment of autoimmune diseases like rheumatoid arthritis and psoriasis. In clinical research, it is used to evaluate the role of pyrimidine synthesis inhibition in modulating immune responses. The compound is employed in combination therapy studies to enhance therapeutic efficacy and in pharmacokinetic research to optimize dosing regimens. Additionally, it serves as a research tool in immunology to investigate DHODH's role in lymphocyte proliferation and in drug discovery to explore novel targets in autoimmune disease treatment. According to "Targeting Metabolic Pathways in Autoimmune Diseases," Orludodstat represents a innovative approach to immunomodulation by disrupting pyrimidine biosynthesis.
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