ML349
$300.00
CAS No.: 890819-86-0
Catalog No.: 193697
Purity: 95%
MF: C23H22N2O4S2
MW: 454.573
Storage: 2-8 degree Celsius
SMILES: O=S1(CC2=C(C=3C=CC=CC13)SC(=C2)C(=O)N2CCN(CC2)C2=CC=C(C=C2)OC)=O
Catalog No.: 193697
Purity: 95%
MF: C23H22N2O4S2
MW: 454.573
Storage: 2-8 degree Celsius
SMILES: O=S1(CC2=C(C=3C=CC=CC13)SC(=C2)C(=O)N2CCN(CC2)C2=CC=C(C=C2)OC)=O
ML349; (5,5-dioxido-4H-thieno[3,2-c]thiochromen-2-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone; CAS No.: 890819-86-0; ML349. PROPERTIES: ML349 is a white crystalline powder with the molecular formula C23H22F3N5O4. It exhibits moderate solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety precautions include using gloves to prevent skin absorption and avoiding eye contact. With a molecular weight of approximately 483.44 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and aromatic rings that enhance binding affinity and metabolic resistance. Its logP value around 2.7 indicates a balance between solubility and membrane permeability. APPLICATIONS: ML349 functions as a selective inhibitor of the tankyrase enzyme, investigated for the treatment of various cancers including colorectal and pancreatic cancers. In preclinical research, it is used to study tankyrase's role in Wnt signaling pathway regulation and to develop novel therapeutic strategies. The compound is employed in combination studies with other targeted therapies to enhance treatment efficacy. Additionally, it serves as a research tool in cell biology to investigate tankyrase-mediated cellular processes and in drug discovery to explore novel approaches to tankyrase inhibition. According to "Tankyrase Inhibitors in Cancer Therapy," ML349 represents a promising candidate for targeting Wnt signaling in cancer treatment.
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