Withaferin A; (4S,4aR,5aR,6aS,6bS,9R,9aS,11aS,11bR)-4-hydroxy-9-((S)-1-((R)-5-(hydroxymethyl)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-9a,11b-dimethyl-5a,6,6a,6b,7,8,9,9a,10,11,11a,11b-dodecahydrocyclopenta[1,2]phenanthro[8a,9-b]oxiren-1(4H)-one; CAS No.: 5119-48-2; Withaferin A. PROPERTIES: Withaferin A is a withanolide compound derived from the plant Withania somnifera. This Withaferin A appears as a white or pale yellow amorphous solid with a molecular weight of 482.67 g/mol. It has limited water solubility but is soluble in organic solvents like DMSO and ethanol. The compound is sensitive to light and should be stored at -20 C in a tightly sealed, light-protected container. It is considered a skin and eye irritant, so appropriate protective measures are necessary. APPLICATIONS: Withaferin A is extensively studied for its anticancer properties, demonstrating activity against various cancer cell lines by inducing apoptosis and inhibiting proliferation. In neurobiology, it shows neuroprotective effects and is investigated for potential applications in neurodegenerative diseases. In immunology, Withaferin A modulates the immune response and exhibits anti-inflammatory activities. These applications are reported in oncology research journals, neuropharmacology studies, and immunology publications.