Dorzolamide HCl; (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride; CAS No.: 130693-82-2; As a Library of Compounds provider, ChemShuttle offers this thienothiopyran sulfonamide hydrochloride, a carbonic anhydrase inhibitor precursor. The 4S,6S-configured dihydrothieno scaffold and ethylamino group enable isoform selectivity engineering. Our synthesis employs novel thiopyran annulation techniques and sulfonamide protection strategies. The 7,7-dioxide formation process highlights our oxidation control capabilities, delivering compounds for ophthalmology and oncology target validation.