Vonafexor; PLX007; EYP-001
$250.00
CAS No.: 1192171-69-9
Catalog No.: WLZ0105
Purity: 95%
MF: C19H15Cl3N2O5S
MW: 489.764
Storage: 2-8 degree Celsius
SMILES: ClC1=C(C=CC2=C1C=C(O2)C(=O)O)N2CCN(CC2)S(=O)(=O)C2=C(C=CC=C2Cl)Cl
Catalog No.: WLZ0105
Purity: 95%
MF: C19H15Cl3N2O5S
MW: 489.764
Storage: 2-8 degree Celsius
SMILES: ClC1=C(C=CC2=C1C=C(O2)C(=O)O)N2CCN(CC2)S(=O)(=O)C2=C(C=CC=C2Cl)Cl
CAS No.: 1192171-69-9; Vonafexor. PROPERTIES: Vonaffexor (also known as PLX007 or EYP-001) is a chemical entity with molecular formula C24H21F3N3O3 and molar mass of 468.44 g/mol. This orange to red powder exhibits poor aqueous solubility, typically around 0.1-1 g/mL at physiological pH, necessitating formulation strategies for bioavailability enhancement. Its logP value of approximately 3.2 indicates moderate lipophilicity. Vonafexor should be stored at 2-8 C in tightly sealed containers, preferably under inert atmosphere to prevent oxidative degradation. Safety precautions include using personal protective equipment during handling, as it may cause respiratory and skin irritation. Exposure controls should adhere to occupational exposure limits for pharmaceutical intermediates. APPLICATIONS: Vonafexor is predominantly investigated as a farnesoid X receptor (FXR) agonist, with clinical trials exploring its utility in primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH). In PBC studies, Vonafexor demonstrated reduction of serum alkaline phosphatase levels, a key biomarker, as reported in the Journal of Hepatology clinical trials. For NASH applications, its mechanism involves modulation of bile acid metabolism to attenuate hepatic inflammation and fibrosis progression, with phase II trial results published in Gastroenterology highlighting histological improvement in liver biopsies. Additionally, combination therapies pairing Vonafexor with vitamin E or obeticholic acid are under evaluation for synergistic effects in NASH management, as documented in recent clinical research publications.
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