FTI277 HCl
$250.00
CAS No.: 180977-34-8
Catalog No.: 193770
Purity: 95%
MF: C22H30ClN3O3S2
MW: 484.087
Storage: 2-8 degree Celsius
SMILES: Cl.N[C@H](CNC1=CC=C(C(=C1)C1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)OC)CS
Catalog No.: 193770
Purity: 95%
MF: C22H30ClN3O3S2
MW: 484.087
Storage: 2-8 degree Celsius
SMILES: Cl.N[C@H](CNC1=CC=C(C(=C1)C1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)OC)CS
FTI277 HCl; methyl (5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-carbonyl)-L-methioninate hydrochloride; CAS No.: 180977-34-8;FTI277 HCl. PROPERTIES: FTI277 HCl is a white or almost white crystalline powder with a molecular formula of C22H25FN4O2 HCl and a molecular weight of 441.93 g/mol. It is moderately soluble in water and highly soluble in organic solvents. Storage recommendations include keeping it at -20 C in a desiccator to prevent moisture absorption. Safety considerations involve using standard laboratory protective equipment due to its potential to cause respiratory irritation if aerosolized. APPLICATIONS: FTI277 HCl is a farnesyltransferase inhibitor targeting RAS signaling pathways. In cancer research, it shows activity against various tumor cell lines expressing activated RAS mutations (source: Clinical Cancer Research). Preclinical studies have evaluated its efficacy in combination with other signaling pathway inhibitors, particularly in pancreatic and colorectal cancer models. FTI277 HCl also serves as a tool compound for studying post-translational modification mechanisms of RAS proteins and their role in tumorigenesis (source: Oncogene).
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