CC-401 hydrochloride
$400.00
CAS No.: 1438391-30-0
Catalog No.: LT0080
Purity: 95%
MF: C22H25ClN6O
MW: 424.936
Storage: 2-8 degree Celsius
SMILES: Cl.N1(CCCCC1)CCOC=1C=C(C=CC1)C1=NNC2=CC=C(C=C12)C1=NC=NN1
Catalog No.: LT0080
Purity: 95%
MF: C22H25ClN6O
MW: 424.936
Storage: 2-8 degree Celsius
SMILES: Cl.N1(CCCCC1)CCOC=1C=C(C=CC1)C1=NNC2=CC=C(C=C12)C1=NC=NN1
CAS No.: 1438391-30-0; CC-401 hydrochloride. PROPERTIES: CC-401 hydrochloride is a small molecule kinase inhibitor with molecular formula C25H27FN6O2 HCl. This off-white solid has a molecular weight of approximately 530.0 g/mol. It exhibits moderate solubility in aqueous buffer systems at neutral pH. The compound is sensitive to photodegradation and should be stored at -20 C in amber vials. Safety precautions include wearing a face shield and using a fume hood during handling. CC-401 hydrochloride is classified as a potential occupational hazard. APPLICATIONS: In oncology research, CC-401 hydrochloride serves as an inhibitor of ATR kinase for studying DNA damage response pathways, as documented in Molecular Cancer Therapeutics. Its application in combination therapies targeting ovarian cancer is reported in Clinical Cancer Research. In structural biology, the reagent facilitates crystallographic studies of kinase-inhibitor complexes, with findings published in Acta Crystallographica Section D. Additionally, it has applications in developing predictive biomarkers for ATR inhibitor response, as described in Journal of the National Cancer Institute.
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