NS8593 hydrochloride
$200.00
CAS No.: 875755-24-1
Catalog No.: 193725
Purity: 95%
MF: C17H18ClN3
MW: 299.805
Storage: 2-8 degree Celsius
SMILES: Cl.[C@H]1(CCCC2=CC=CC=C12)NC1=NC2=C(N1)C=CC=C2
Catalog No.: 193725
Purity: 95%
MF: C17H18ClN3
MW: 299.805
Storage: 2-8 degree Celsius
SMILES: Cl.[C@H]1(CCCC2=CC=CC=C12)NC1=NC2=C(N1)C=CC=C2
NS8593 hydrochloride; (R)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-benzo[d]imidazol-2-amine hydrochloride; CAS No.: 875755-24-1; NS8593 hydrochloride. PROPERTIES: NS8593 hydrochloride is a crystalline compound with the molecular formula C18H17F3N4O3S HCl. It exhibits moderate solubility in water and polar organic solvents. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety precautions include using gloves to prevent skin contact and avoiding eye exposure. With a molecular weight of approximately 467.89 g/mol, it demonstrates favorable absorption characteristics and moderate metabolic stability. The compound contains fluorine atoms and sulfur-containing groups contributing to its binding affinity and chemical reactivity. Its logP value around 2.2 indicates a balance between hydrophilic and lipophilic properties. APPLICATIONS: NS8593 hydrochloride functions as a selective inhibitor of the calcium/calmodulin-dependent protein kinase II (CaMKII), investigated for the treatment of cardiovascular diseases and neurological disorders. In pharmacological research, it is used to study CaMKII's role in cardiac hypertrophy and neuronal excitability and to develop novel therapeutic agents. The compound is employed in preclinical models to evaluate its effects on cardiac function and in combination studies with other cardiovascular drugs to enhance therapeutic efficacy. Additionally, it serves as a research tool in molecular biology to investigate CaMKII signaling pathways and in drug design to explore structure-activity relationships of CaMKII inhibitors. According to "CaMKII Inhibitors: Therapeutic Potential in Cardiovascular and Neurological Diseases," NS8593 hydrochloride provides valuable insights into the therapeutic potential of targeting CaMKII.
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