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DL-AP5; 2-amino-5-phosphonopentanoic acid; CAS No.: 76326-31-3; DL-AP5. PROPERTIES: DL-AP5 is a white crystalline compound with the molecular formula C5H10N2O2S. It exhibits good solubility in water and polar organic solvents. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety considerations include using gloves to prevent skin contact and avoiding eye exposure. With a molecular weight of approximately 174.21 g/mol, it demonstrates favorable absorption characteristics and moderate metabolic stability. The compound contains sulfhydryl groups contributing to its chemical reactivity and biological activity. Its logP value around 0.9 indicates a predominantly hydrophilic nature. APPLICATIONS: DL-AP5 serves as a competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, investigated in neuroscience research and the study of neurodegenerative diseases. In pharmacological research, it is used to study NMDA receptor physiology and pathophysiology and to develop novel neuroprotective agents. The compound is employed in preclinical models to evaluate effects on neuronal excitability and in combination studies with other neuroprotective agents to enhance therapeutic efficacy. Additionally, it functions as a research tool in neuropharmacology to investigate NMDA receptor subtype selectivity and in drug design to explore structure-activity relationships of NMDA receptor antagonists. According to "NMDA Receptor Antagonists: From Basic Research to Clinical Applications," DL-AP5 provides valuable insights into the therapeutic potential of targeting NMDA receptors in neurological disorders.