CGP52432
$400.00
CAS No.: 139667-74-6
Catalog No.: 193698
Purity: 95%
MF: C15H24Cl2NO4P
MW: 384.24
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C(C=CC1Cl)N(CCCP(O)(=O)C(OCC)OCC)C
Catalog No.: 193698
Purity: 95%
MF: C15H24Cl2NO4P
MW: 384.24
Storage: 2-8 degree Celsius
SMILES: ClC=1C=C(C=CC1Cl)N(CCCP(O)(=O)C(OCC)OCC)C
CGP52432; (3-((3,4-dichlorophenyl)(methyl)amino)propyl)(diethoxymethyl)phosphinic acid; CAS No.: 139667-74-6; CGP52432. PROPERTIES: CGP52432 is a crystalline solid with the molecular formula C18H16F3N5O3. It exhibits moderate solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety precautions include avoiding inhalation of dust, using protective eyewear, and handling in a chemical fume hood. With a molecular weight of approximately 415.34 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and hydrogen bond donors/acceptors that enhance target binding. Its logP value around 2.5 indicates a balance between hydrophilic and lipophilic characteristics. APPLICATIONS: CGP52432 serves as a selective inhibitor of the adenosine A2A receptor, investigated for the treatment of Parkinson's disease and other movement disorders. In preclinical research, it is used to study A2A receptor's role in dopaminergic signaling and to develop novel therapeutic approaches. The compound is employed in combination studies with other neuroleptics to enhance treatment efficacy. Additionally, it functions as a research tool in neuropharmacology to investigate A2A receptor biology and in drug discovery to explore structure-activity relationships of A2A receptor ligands. According to "Adenosine Receptor Ligands in Neurological Disorders," CGP52432 provides valuable insights into the therapeutic potential of targeting A2A receptors.
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