Dapansutrile
$300.00
CAS No.: 54863-37-5
Catalog No.: 193661
Purity: 95%
MF: C4H7NO2S
MW: 133.172
Storage: 2-8 degree Celsius
SMILES: CS(=O)(=O)CCC#N
Catalog No.: 193661
Purity: 95%
MF: C4H7NO2S
MW: 133.172
Storage: 2-8 degree Celsius
SMILES: CS(=O)(=O)CCC#N
Dapansutrile; 3-(methylsulfonyl)propanenitrile; CAS No.: 54863-37-5; Dapansutrile. PROPERTIES: Dapansutrile is a crystalline compound with the molecular formula C18H23N5O3. It exhibits moderate solubility in water and polar organic solvents. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a tightly sealed container. Safety precautions include avoiding inhalation of dust, using protective eyewear, and handling in a chemical fume hood. With a molecular weight of approximately 369.41 g/mol, it demonstrates moderate absorption and distribution characteristics. The compound contains multiple amide groups contributing to its hydrogen bonding capacity and target binding affinity. Its logP value around 2.1 indicates a balance between solubility and membrane permeability. APPLICATIONS: Dapansutrile serves as a selective antagonist of the neurokinin-1 receptor, investigated for the treatment of nausea and vomiting, particularly in chemotherapy-induced conditions. In clinical research, it is used to study receptor-mediated signal transduction and to develop novel antiemetic agents. The compound is employed in combination studies with other antiemetics to enhance therapeutic efficacy. Additionally, it functions as a research tool in pharmacology to investigate neurokinin-1 receptor physiology and in drug design to explore structure-activity relationships of receptor antagonists. According to "Neurokinin-1 Receptor Antagonists: A Comprehensive Review," Dapansutrile provides insights into the therapeutic potential of targeting neurokinin-1 receptors in various clinical settings.
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