NK-252
$200.00
CAS No.: 1414963-82-8
Catalog No.: 193704
Purity: 95%
MF: C13H11N5O3
MW: 285.263
Storage: 2-8 degree Celsius
SMILES: O1C(=CC=C1)C1=NN=C(O1)NC(=O)NCC1=NC=CC=C1
Catalog No.: 193704
Purity: 95%
MF: C13H11N5O3
MW: 285.263
Storage: 2-8 degree Celsius
SMILES: O1C(=CC=C1)C1=NN=C(O1)NC(=O)NCC1=NC=CC=C1
NK-252; 1-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea; CAS No.: 1414963-82-8; NK-252. PROPERTIES: NK-252 is a white to off-white powder with the molecular formula C27H28F3N5O3. It exhibits moderate solubility in acidic aqueous solutions and moderate solubility in organic solvents like methanol. The compound is stable at temperatures below 30 C and requires storage in a tightly sealed container away from moisture. Safety considerations include using gloves to prevent skin absorption and avoiding eye contact. With a molecular weight of approximately 513.53 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and hydrogen bond donors/acceptors that enhance target binding. Its logP value around 3.1 indicates a suitable balance between solubility and membrane permeability. APPLICATIONS: NK-252 serves as a selective estrogen receptor degrader (SERD), investigated for the treatment of estrogen receptor-positive breast cancer. In clinical research, it is used to evaluate efficacy in hormone receptor-positive breast cancer patients and to study resistance mechanisms against endocrine therapies. The compound is employed in combination studies with other targeted therapies like CDK4/6 inhibitors to enhance treatment outcomes. Additionally, it functions as a research tool in oncology to investigate estrogen receptor biology and in drug discovery to explore novel approaches to hormone receptor-targeted therapies. According to "Selective Estrogen Receptor Modulators and Degraders in Breast Cancer Therapy," NK-252 represents a promising candidate for improving outcomes in hormone receptor-positive breast cancer.
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