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Emedastine; 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzo[d]imidazole; CAS No.: 87233-61-2;Emedastine. PROPERTIES: Emedastine is a white or almost white crystalline powder with a molecular formula of C22H26N2O2 and a molecular weight of 350.45 g/mol. It has a slightly bitter taste and is practically insoluble in water but dissolves in methanol and ethanol. For storage, it should be kept in a cool, dry place below 25 C in a well-closed container. Safety precautions include avoiding inhalation of dust and preventing skin and eye contact as it may cause mild irritation. APPLICATIONS: Emedastine is a second-generation histamine H1-receptor antagonist used primarily in ophthalmology. It effectively relieves ocular itching and redness associated with allergic conjunctivitis by selectively blocking histamine receptors on conjunctival tissue (source: Clinical Ophthalmology). Topical application in eye drops formulation minimizes systemic absorption, reducing common antihistamine side effects like drowsiness. Emedastine has also been studied for nasal allergy treatment, providing rapid relief from rhinitis symptoms when administered as nasal sprays (source: Allergy and Asthma Proceedings).