AZD8797( KAND567)
$600.00
CAS No.: 911715-90-7
Catalog No.: 198911
Purity: 95%
MF: C19H25N5OS2
MW: 403.577
Storage: 2-8 degree Celsius
SMILES: NC=1SC2=C(N=C(N=C2N[C@@H](CO)CC(C)C)S[C@@H](C)C2=CC=CC=C2)N1
Catalog No.: 198911
Purity: 95%
MF: C19H25N5OS2
MW: 403.577
Storage: 2-8 degree Celsius
SMILES: NC=1SC2=C(N=C(N=C2N[C@@H](CO)CC(C)C)S[C@@H](C)C2=CC=CC=C2)N1
CAS No.: 911715-90-7; AZD8797 (KAND567). PROPERTIES: AZD8797, also known as KAND567, is a white to off-white crystalline solid with a molecular weight of approximately 394.4 g/mol. Its chemical formula is C19H22F3N3O2. The compound exhibits poor aqueous solubility, typically requiring dimethyl sulfoxide (DMSO) as a solvent for biological assays. AZD8797 should be stored at -20 C in tightly sealed containers under inert atmosphere to prevent degradation. Safety precautions include using personal protective equipment (PPE) such as gloves and goggles during handling. The compound is classified as harmful if swallowed and may cause serious eye irritation. APPLICATIONS: AZD8797 is primarily investigated as a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP-4), making it a candidate for type 2 diabetes treatment. In vitro studies demonstrate its ability to potentiate glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by inhibiting their degradation. Preclinical animal models show improved glucose tolerance and insulin secretion following AZD8797 administration. The compound has also been explored in oncology research due to its potential effects on tumor microenvironment modulation. In cancer cell lines, AZD8797 demonstrates antiproliferative effects by altering immune cell infiltration. These applications are supported by documentation from AstraZeneca's pharmaceutical research publications.
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