Astemizole
$300.00
CAS No.: 68844-77-9
Catalog No.: 193743
Purity: 95%
MF: C28H31FN4O
MW: 458.581
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(CN2C(=NC3=C2C=CC=C3)NC3CCN(CC3)CCC3=CC=C(C=C3)OC)C=C1
Catalog No.: 193743
Purity: 95%
MF: C28H31FN4O
MW: 458.581
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(CN2C(=NC3=C2C=CC=C3)NC3CCN(CC3)CCC3=CC=C(C=C3)OC)C=C1
Astemizole; 1-(4-fluorobenzyl)-N-(1-(4-methoxyphenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-amine; CAS No.: 68844-77-9;Astemizole. PROPERTIES: Astemizole is a white or almost white powder with a molecular formula of C27H31ClN2O and a molecular weight of 438.01 g/mol. It has low water solubility but dissolves in common organic solvents. Storage should be at room temperature in a tightly closed container protected from moisture. Safety considerations include avoiding ingestion and eye contact, with standard pharmaceutical handling precautions. APPLICATIONS: Astemizole is a long-acting histamine H1-receptor antagonist previously used in allergy treatment. Its primary application was for relieving symptoms of seasonal allergic rhinitis and chronic urticaria through selective receptor blockade (source: Journal of Allergy and Clinical Immunology). Due to cardiac safety concerns, particularly QT interval prolongation, its use has been discontinued in many countries. However, astemizole remains a valuable reference compound in pharmaceutical research for studying antihistamine pharmacology and cardiotoxicity mechanisms (source: Drug Safety).
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