(+)-JQ1; JQ1
$200.00
CAS No.: 1268524-70-4
Catalog No.: 109721
Purity: 95%
MF: C23H25ClN4O2S
MW: 456.999
Storage: 2-8 degree Celsius
SMILES: CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)OC(C)(C)C)N=C2C1=CC=C(Cl)C=C1
Catalog No.: 109721
Purity: 95%
MF: C23H25ClN4O2S
MW: 456.999
Storage: 2-8 degree Celsius
SMILES: CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)OC(C)(C)C)N=C2C1=CC=C(Cl)C=C1
CAS NO.: 1268524-70-4; (S)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate ((+)-JQ1; JQ1). PROPERTIES: (+)-JQ1 is a solid compound with a complex heterocyclic structure. It has limited solubility in water and is more soluble in organic solvents such as dimethyl sulfoxide (DMSO). This compound should be stored at -20 C in a tightly sealed container, away from light and moisture to maintain its stability. In terms of safety, it may be harmful if inhaled, swallowed, or in contact with skin. Appropriate personal protective equipment, including gloves and lab coats, should be worn when handling it. APPLICATIONS: (+)-JQ1 is widely used in biological research, especially in the study of epigenetic regulation. It acts as a selective inhibitor of bromodomain and extra-terminal (BET) proteins. By binding to the bromodomains of BET proteins, it disrupts the interaction between these proteins and acetylated histones, thereby interfering with gene transcription processes. This property makes it valuable in cancer research, as BET proteins are involved in the regulation of genes related to cell proliferation and survival. Its application in understanding epigenetic mechanisms and developing cancer therapies is supported by numerous studies in the fields of molecular biology and oncology.
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