WM-3835
$300.00
CAS No.: 2229025-70-9
Catalog No.: 193688
Purity: 95%
MF: C20H17FN2O4S
MW: 400.431
Storage: 2-8 degree Celsius
SMILES: FC1=C(C=C(C=C1C)C1=CC=CC=C1)C(=O)NNS(=O)(=O)C1=CC(=CC=C1)O
Catalog No.: 193688
Purity: 95%
MF: C20H17FN2O4S
MW: 400.431
Storage: 2-8 degree Celsius
SMILES: FC1=C(C=C(C=C1C)C1=CC=CC=C1)C(=O)NNS(=O)(=O)C1=CC(=CC=C1)O
WM-3835; N'-(4-fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide; CAS No.: 2229025-70-9; WM-3835. PROPERTIES: WM-3835 is a white to off-white powder with the molecular formula C23H22F3N5O4. It exhibits moderate solubility in acidic aqueous solutions and moderate solubility in organic solvents like methanol. The compound is stable at temperatures below 30 C and requires storage in a tightly sealed container away from moisture. Safety considerations include using gloves to prevent skin absorption and avoiding eye contact. With a molecular weight of approximately 483.44 g/mol, it demonstrates moderate bioavailability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and hydrogen bond donors/acceptors that contribute to its binding affinity. Its logP value around 2.7 indicates a balance between hydrophilic and lipophilic characteristics. APPLICATIONS: WM-3835 serves as a potent and selective inhibitor of the mechanistic target of rapamycin complex 1 (mTORC1), investigated for anticancer therapy and the treatment of other mTOR-driven diseases. In preclinical research, it is used to study mTOR signaling pathways and to develop novel therapeutic strategies. The compound is employed in combination studies with other targeted therapies to enhance antitumor efficacy. Additionally, it functions as a research tool in cell biology to investigate mTOR-mediated cellular processes and in drug discovery to explore novel approaches to mTOR inhibition. According to "mTOR Inhibitors: A Comprehensive Review," WM-3835 represents a promising candidate for modulating mTOR signaling in various disease contexts.
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