E-7386
$300.00
CAS No.: 1799824-08-0
Catalog No.: 194335
Purity: 95%
MF: C39H48FN9O4
MW: 725.87
Storage: 2-8 degree Celsius
SMILES: C(C=C)N1N([C@@H]2N(C(C1)=O)[C@H](C(N(C2)CC2=NC(=CC=C2)N2CC(C2)N2CCN(CC2)CC)=O)CC2=C(C=C(C=C2)O)F)C(=O)NCC2=CC=CC=C2
Catalog No.: 194335
Purity: 95%
MF: C39H48FN9O4
MW: 725.87
Storage: 2-8 degree Celsius
SMILES: C(C=C)N1N([C@@H]2N(C(C1)=O)[C@H](C(N(C2)CC2=NC(=CC=C2)N2CC(C2)N2CCN(CC2)CC)=O)CC2=C(C=C(C=C2)O)F)C(=O)NCC2=CC=CC=C2
E-7386; (6S,9aS)-2-allyl-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide; CAS No.: 1799824-08-0;E-7386. PROPERTIES: E-7386 is a white to pale yellow crystalline solid with a molecular formula of C27H27F3N4O4 and a molecular weight of 546.53 g/mol. It has moderate solubility in water and better solubility in common organic solvents. Proper storage requires maintaining at -20 C in a sealed container protected from light. When handling, standard laboratory protective equipment should be used due to its experimental nature and potential unknown chronic effects. APPLICATIONS: E-7386 is a potent inhibitor of the kinase insert domain receptor (KDR/VEGFR2). In oncology research, it demonstrates antitumor activity by inhibiting angiogenesis in various cancer models (source: Cancer Research). Preclinical studies have shown efficacy in combination with chemotherapeutic agents, enhancing treatment responses through dual mechanisms of action. E-7386 also serves as a tool for compound studying VEGF signaling pathways and their role in tumor microenvironment remodeling (source: Molecular Cancer Therapeutics).
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