BMS-P5
$500.00
CAS No.: 1550371-22-6
Catalog No.: 193665
Purity: 95%
MF: C27H32N6O2
MW: 472.593
Storage: 2-8 degree Celsius
SMILES: N[C@@H]1CC[C@@H](N(C1)C(=O)C1=CC2=C(N(C(=N2)C2=CC=3C(=NC=CC3)N2CC2CC2)C)C(=C1)OC)C
Catalog No.: 193665
Purity: 95%
MF: C27H32N6O2
MW: 472.593
Storage: 2-8 degree Celsius
SMILES: N[C@@H]1CC[C@@H](N(C1)C(=O)C1=CC2=C(N(C(=N2)C2=CC=3C(=NC=CC3)N2CC2CC2)C)C(=C1)OC)C
BMS-P5; ((2S,5R)-5-amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone; CAS No.: 1550371-22-6; BMS-P5. PROPERTIES: BMS-P5 is a crystalline compound with the molecular formula C24H22F3N5O3. It exhibits moderate solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at temperatures below 30 C and requires storage in a tightly sealed container away from moisture. Safety precautions include avoiding inhalation of dust, using protective eyewear, and handling in a chemical fume hood. With a molecular weight of approximately 511.46 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms that contribute to its binding affinity and metabolic resistance. Its logP value around 2.7 indicates a balance between solubility and membrane permeability. APPLICATIONS: BMS-P5 functions as a potent and selective inhibitor of the Bruton's tyrosine kinase (BTK), investigated for the treatment of B-cell malignancies and autoimmune diseases. In preclinical research, it is used to study BTK's role in B-cell receptor signaling and to develop novel therapeutic approaches. The compound is employed in combination studies with other targeted therapies to enhance antitumor efficacy. Additionally, it serves as a research tool in immunology to investigate B-cell biology and in drug discovery to explore structure-activity relationships of BTK inhibitors. According to "Bruton's Tyrosine Kinase as a Therapeutic Target in Oncology and Immunology," BMS-P5 provides a valuable platform for targeting BTK-mediated signaling pathways.
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