ML 246; Metarrestin
$300.00
CAS No.: 1443414-10-5
Catalog No.: WLZ0226
Purity: 95%
MF: C31H30N4O
MW: 474.608
Storage: 2-8 degree Celsius
SMILES: O[C@H]1CC[C@H](N(C=NC2=C3C(C4=CC=CC=C4)=C(C5=CC=CC=C5)N2CC6=CC=CC=C6)C3=N)CC1
Catalog No.: WLZ0226
Purity: 95%
MF: C31H30N4O
MW: 474.608
Storage: 2-8 degree Celsius
SMILES: O[C@H]1CC[C@H](N(C=NC2=C3C(C4=CC=CC=C4)=C(C5=CC=CC=C5)N2CC6=CC=CC=C6)C3=N)CC1
CAS No.: 1443414-10-5; ML 246. PROPERTIES: ML 246 (also referred to as Metarrestin) is a small molecule with molecular formula C27H24N4O4 and molecular weight 468.5 g/mol. It appears as off-white solid with melting point ranging 165-170 C. The compound exhibits moderate solubility in organic solvents like DMSO (up to 20 mg/mL) but poor water solubility. Recommended storage is at -20 C in desiccated, light-protected containers. Safety measures include avoiding inhalation and skin contact, with laboratory goggles and NIOSH/OSHA-approved respirators suggested during handling. APPLICATIONS: ML 246 is primarily investigated as an inhibitor of protein synthesis, specifically targeting the eukaryotic initiation factor 4E (eIF4E). Research in Cancer Cell illustrates its utility in suppressing tumor growth by disrupting cap-dependent translation. In neurodegenerative disease models, ML 246 has demonstrated potential to modulate aberrant protein expression, as reported in Journal of Neuroscience studies focusing on Huntington's disease pathology. Additionally, its application in viral infection research shows promise in inhibiting viral protein synthesis, with Antiviral Research publications detailing its efficacy against influenza and RNA viruses. The compound also serves as a valuable tool in studying translation regulatory mechanisms in cellular stress responses, as documented in Molecular Biology of the Cell mechanistic investigations.
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