MK-8719
$300.00
CAS No.: 1382799-40-7
Catalog No.: 193662
Purity: 95%
MF: C9H14F2N2O3S
MW: 268.285
Storage: 2-8 degree Celsius
SMILES: FC([C@@H]1[C@H]([C@@H]([C@H]2N\C(\S[C@H]2O1)=N/CC)O)O)F
Catalog No.: 193662
Purity: 95%
MF: C9H14F2N2O3S
MW: 268.285
Storage: 2-8 degree Celsius
SMILES: FC([C@@H]1[C@H]([C@@H]([C@H]2N\C(\S[C@H]2O1)=N/CC)O)O)F
MK-8719; (3aR,5S,6S,7R,7aR,E)-5-(difluoromethyl)-2-(ethylimino)hexahydro-1H-pyrano[3,2-d]thiazole-6,7-diol; CAS No.: 1382799-40-7; MK-8719. PROPERTIES: MK-8719 is a white to pale yellow powder with the molecular formula C25H29N5O4. It exhibits good solubility in basic aqueous solutions and moderate solubility in organic solvents like methanol. The compound is stable at temperatures below 30 C and requires storage in a desiccator to prevent moisture degradation. Safety considerations include using chemical-resistant gloves, avoiding skin contact, and ensuring proper disposal of waste materials. With a molecular weight of approximately 467.53 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple hydrogen bond donors and acceptors that enhance target binding. Its logP value around 2.8 indicates a suitable balance between solubility and membrane permeability. APPLICATIONS: MK-8719 functions as a selective inhibitor of dipeptidyl peptidase-4 (DPP-4), investigated for the treatment of type 2 diabetes mellitus. In clinical research, it is used to evaluate glucose-lowering effects and to study the role of incretin hormones in glucose homeostasis. The compound is employed in combination therapy studies with other antidiabetic agents to enhance treatment efficacy. Additionally, it serves as a research tool in endocrinology to investigate DPP-4's physiological functions and in drug discovery to explore novel approaches to diabetes management. According to "Dipeptidyl Peptidase-4 Inhibitors in Diabetes Therapy," MK-8719 represents a promising candidate for improving glycemic control with a favorable side effect profile.
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