Fmoc-Gly3-Val-Cit-PAB
$600.00
CAS No.: 2647914-09-6
Catalog No.: 198452
Purity: 95%
MF: C39H48N8O9
MW: 772.86
Storage: 2-8 degree Celsius
SMILES: NC(NCCC[C@H](NC([C@@H](NC(CNC(CNC(CNC(OCC1C2=CC=CC=C2C=2C=CC=CC12)=O)=O)=O)=O)C(C)C)=O)C(NC1=CC=C(C=C1)CO)=O)=O
Catalog No.: 198452
Purity: 95%
MF: C39H48N8O9
MW: 772.86
Storage: 2-8 degree Celsius
SMILES: NC(NCCC[C@H](NC([C@@H](NC(CNC(CNC(CNC(OCC1C2=CC=CC=C2C=2C=CC=CC12)=O)=O)=O)=O)C(C)C)=O)C(NC1=CC=C(C=C1)CO)=O)=O
CAS No.: 2647914-09-6; Fmoc-Gly3-Val-Cit-PAB. PROPERTIES: Fmoc-Gly3-Val-Cit-PAB is a protected peptide derivative with molecular formula C49H63N8O10 and molecular weight 925.06 g/mol. It typically appears as a white to off-white powder with limited solubility in water, requiring dimethylformamide or dimethyl sulfoxide for dissolution. The compound is sensitive to basic conditions and should be stored at 2-8 C in a tightly sealed container. Safety precautions include avoiding skin contact and using protective equipment due to potential irritancy. APPLICATIONS: In bioconjugation chemistry, Fmoc-Gly3-Val-Cit-PAB serves as a linker molecule for attaching payloads to antibodies or other targeting moieties. The Fmoc group allows for temporary protection during synthesis, while the Gly3-Val-Cit sequence contains a cathepsin B cleavable site for intracellular release of attached drugs. The PAB (para-aminobenzyl) group facilitates conjugation via its amine functionality. In pharmaceutical research, this compound is used in developing antibody-drug conjugates (ADCs) where the linker must balance stability in circulation with efficient intracellular payload release. The Gly3-Val-Cit sequence is specifically cleaved by lysosomal proteases in cancer cells, enabling targeted drug delivery with reduced off-target effects. Additionally, the compound is utilized in chemical biology to study protease activity in cellular contexts and to develop prodrugs activated by specific intracellular proteolytic environments. The Fmoc protection strategy allows stepwise synthesis of complex bioconjugates with precise control over conjugation sites. (Bioconjugation chemistry literature and pharmaceutical research articles)
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