N1-Methylpseudouridine
$600.00
CAS No.: 13860-38-3
Catalog No.: WLZ1477
Purity: 95%
MF: C10H14N2O6
MW: 258.23
Storage: 2-8 degree Celsius
SMILES: [C@H](O)1[C@@H](CO)O[C@@H](C2C(=O)NC(=O)N(C)C=2)[C@@H]1O
Catalog No.: WLZ1477
Purity: 95%
MF: C10H14N2O6
MW: 258.23
Storage: 2-8 degree Celsius
SMILES: [C@H](O)1[C@@H](CO)O[C@@H](C2C(=O)NC(=O)N(C)C=2)[C@@H]1O
CAS No.: 13860-38-3; N1-Methylpseudouridine. PROPERTIES: N1-Methylpseudouridine is a modified nucleoside with molecular formula C10H14N2O5 and molar mass 246.2 g/mol. It exists as white crystalline solid with melting point 178-180 C. The compound is moderately soluble in water ( 10 mg/mL) and freely soluble in ethanol. Recommended storage is at room temperature in sealed containers. Safety considerations include standard laboratory precautions, as it presents minimal acute toxicity but potential for chronic exposure effects. APPLICATIONS: In mRNA therapeutics, N1-Methylpseudouridine serves as a nucleoside modifier to enhance translation efficiency and reduce immunogenicity. Its application in COVID-19 vaccine development is detailed in Nature publications describing the lipid nanoparticle formulation and immune response optimization. For gene therapy vectors, the modified nucleoside improves mRNA stability and expression duration, as reported in Molecular Therapy preclinical studies. In synthetic biology, N1-Methylpseudouridine expands the coding capacity of genetic systems, with Journal of the American Chemical Society articles describing its incorporation into expanded genetic codes. Additionally, researchers utilize this reagent in studying RNA structure and function, with RNA journal publications outlining its role in creating thermodynamically stabilized RNA structures for binding assays.
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