DMT-2'Fluoro-DG(IB) Amidite
$300.00
CAS No.: 144089-97-4
Catalog No.: 194883
Purity: 95%
MF: C44H53FN7O8P
MW: 857.921
Storage: 2-8 degree Celsius
SMILES: C(C)(C)N(P(O[C@@H]1[C@H](O[C@H]([C@@H]1F)N1C=2N=C(NC(C2N=C1)=O)NC(C(C)C)=O)COC(C1=CC=CC=C1)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OC)OCCC#N)C(C)C
Catalog No.: 194883
Purity: 95%
MF: C44H53FN7O8P
MW: 857.921
Storage: 2-8 degree Celsius
SMILES: C(C)(C)N(P(O[C@@H]1[C@H](O[C@H]([C@@H]1F)N1C=2N=C(NC(C2N=C1)=O)NC(C(C)C)=O)COC(C1=CC=CC=C1)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OC)OCCC#N)C(C)C
DMT-2'Fluoro-DG(IB) Amidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; CAS No.: 144089-97-4;DMT-2'Fluoro-DG(IB) Amidite. PROPERTIES: DMT-2'Fluoro-DG(IB) Amidite is a white to pale yellow solid with a molecular formula of C55H56F6N9O8 and a molecular weight of 1125.07 g/mol. It exhibits limited aqueous solubility but dissolves well in common organic solvents like dichloromethane and tetrahydrofuran. Proper storage requires maintaining it at -20 C in a sealed amber vial protected from light and moisture. When handling, chemical-resistant gloves and eye protection are essential due to its potential to cause skin and eye irritation. APPLICATIONS: DMT-2'Fluoro-DG(IB) Amidite is a phosphoramidite building block used in oligonucleotide synthesis. In medicinal chemistry, it enables incorporation of 2'-fluoro-modified ribonucleotides into synthetic oligonucleotides, enhancing their stability and binding affinity (source: Nucleic Acids Research). The compound's unique chemical structure facilitates automated DNA/RNA synthesis processes, particularly in developing antisense therapeutics and siRNA molecules. Additionally, it serves as a research tool for studying RNA structure-function relationships and improving nucleic acid-based diagnostic probes (source: Bioconjugate Chemistry).
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