Pretomanid (PA-824; PA824; PA 824; (S)-PA 824)
$400.00
CAS No.: 187235-37-6
Catalog No.: 140130
Purity: 95%
MF: C14H12F3N3O5
MW: 359.26
Storage: 2-8 degree Celsius
SMILES: [O-][N+](=O)C1=CN2C[C@@H](COC2=N1)OCC1=CC=C(OC(F)(F)F)C=C1
Catalog No.: 140130
Purity: 95%
MF: C14H12F3N3O5
MW: 359.26
Storage: 2-8 degree Celsius
SMILES: [O-][N+](=O)C1=CN2C[C@@H](COC2=N1)OCC1=CC=C(OC(F)(F)F)C=C1
CAS NO.: 187235-37-6; (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (Pretomanid (PA-824; PA824; PA 824; (S)-PA 824)). PROPERTIES: Pretomanid is a yellow crystalline solid with a molecular weight of ~431 g/mol. It is sparingly soluble in water but soluble in organic solvents like methanol. The compound is stable under refrigeration when stored in a light-protected container. As an antitubercular agent, it should be handled with care, though its toxicity profile is low in preclinical studies. APPLICATIONS: Pretomanid is an oral drug used in combination therapies for treating multidrug-resistant tuberculosis (MDR-TB). It inhibits mycobacterial cell wall synthesis by targeting the decaprenylphosphoryl- -D-ribose 2'-epimerase (DprE1) enzyme. Clinical trials have shown its efficacy in shortening treatment duration for MDR-TB. This application is supported by tuberculosis research and World Health Organization (WHO) treatment guidelines.
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