5′-Guanylic acid, 7-methyl-, monoanhydride with 1Himidazol-1-ylphosphonic acid, disodium salt
$250.00
CAS No.: 852155-68-1
Catalog No.: WLZ1492
Purity: 95%
MF: C14H21N7NaO10P2+
MW: 532.299
Storage: 2-8 degree Celsius
SMILES: C[N+]1=CN([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(N3C=NC=C3)(O)=O)O2)O)C2NC(N)=NC(=O)C1=2.[NaH]
Catalog No.: WLZ1492
Purity: 95%
MF: C14H21N7NaO10P2+
MW: 532.299
Storage: 2-8 degree Celsius
SMILES: C[N+]1=CN([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(N3C=NC=C3)(O)=O)O2)O)C2NC(N)=NC(=O)C1=2.[NaH]
CAS No.: 852155-68-1; 5 -Guanylic acid, 7-methyl-, monoanhydride with 1Himidazol-1-ylphosphonic acid, disodium salt. PROPERTIES: This complex nucleotide derivative has molecular formula C12H13N5Na2O9P2 and molar mass 524.2 g/mol. It appears as white amorphous powder with hygroscopic nature. The compound is freely soluble in water (up to 100 mg/mL) but hydrolytically unstable above pH 8. Recommended storage is at 4 C in sealed polyethylene containers. Safety precautions include using closed-system transfers to prevent hygroscopic caking and wearing respiratory protection during powder handling. APPLICATIONS: The compound serves as a building block in creating stabilized guanylate analogs for enzymatic studies. In signal transduction research, it functions as a GMP derivative with enhanced resistance to nucleases, as described in Biochemical Journal method development articles. For aptamer development, the modified guanylate contributes to improved binding affinity and specificity, with Nucleic Acid Therapeutics publications detailing applications in creating RNA aptamers against protein targets. In diagnostic assays, the compound is utilized in creating guanine-based fluorescent probes, with Analytical Biochemistry articles outlining its application in PCR detection systems. Additionally, researchers employ this reagent in studying guanylate kinase mechanisms, with Journal of Biological Chemistry mechanistic investigations highlighting its role in enzyme inhibition studies.
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