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(R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid; CAS No.: 13244-78-5; (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid. PROPERTIES: This compound appears as a white to off-white crystalline solid with molecular formula C9H10O4 and a molecular weight of 186.17 g/mol. It exhibits a melting point in the range of 178-182 C and demonstrates moderate solubility in common organic solvents like methanol and ethyl acetate. The substance is sensitive to oxidation and should be stored under inert atmosphere. Recommended storage involves maintaining in tightly sealed containers at temperatures below 25 C, protected from moisture and light. When handling, standard laboratory safety protocols should be followed, including the use of protective gloves and eye wear, as (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid may cause skin irritation. The hydroxyl groups require careful handling in strongly acidic environments. APPLICATIONS: In medicinal chemistry, (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid serves as a key intermediate for synthesizing antiviral agents, as documented in pharmaceutical research focusing on nucleoside analogs. Its hydroxyl substituents enable formation of bioactive esters through esterification reactions. Additionally, this compound functions as a building block for preparing agrochemicals with herbicidal activities through coupling reactions. Academic studies have explored its potential in bioconjugation reactions for creating targeted therapeutic agents, as reported in biochemical journals. The dihydroxyphenyl ring system also facilitates coordination with metal ions, making it valuable for creating luminescent materials in materials science applications, as evidenced by inorganic chemistry publications.