(R)-2-chlorobutanoic acid
$250.00
CAS No.: 54053-45-1
Catalog No.: TQP0742
Purity: 95%
MF: C4H7ClO2
MW: 122.551
Storage: 2-8 degree Celsius
SMILES: Cl[C@@H](C(=O)O)CC
Catalog No.: TQP0742
Purity: 95%
MF: C4H7ClO2
MW: 122.551
Storage: 2-8 degree Celsius
SMILES: Cl[C@@H](C(=O)O)CC
CAS NO.: 54053-45-1;(R)-2-chlorobutanoic acid. PROPERTIES: This chiral chlorinated fatty acid presents as a colorless liquid with a molecular weight of approximately 127.6 g/mol. The (R)-2-chlorobutanoic acid combines a chiral center with a chlorine substituent on a butanoic acid chain. It exhibits limited aqueous solubility but good dissolution in lower alcohols and ethyl acetate. Stability characterization reveals sensitivity to base-catalyzed elimination and light exposure, necessitating storage at 2-8 degree Celsius in amber glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause mild irritation requiring thorough washing. Inhalation may induce respiratory tract irritation; treatment includes fresh air and medical evaluation. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The (R)-2-chlorobutanoic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its chiral butanoic acid framework provides opportunities for constructing muscarinic receptor modulators and beta-blockers. Research teams utilize this compound as a starting material for creating antipsychotic agents and serotonin receptor modulators. The chlorinated alpha position enhances metabolic resistance compared to non-chlorinated analogs. Additionally, it undergoes reductive amination for constructing tertiary amines with defined stereochemistry. The compound's versatility makes it valuable in the development of GABA receptor modulators and enzyme inhibitors.
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