(R)-1-isopropyl-2-methylpiperazine dihydrochloride
$225.00
CAS No.: 2173637-34-6
Catalog No.: 192796
Purity: 95%
MF: C8H20Cl2N2
MW: 215.168
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.C(C)(C)N1[C@@H](CNCC1)C
Catalog No.: 192796
Purity: 95%
MF: C8H20Cl2N2
MW: 215.168
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.C(C)(C)N1[C@@H](CNCC1)C
(R)-1-isopropyl-2-methylpiperazine dihydrochloride; CAS No.: 2173637-34-6; (R)-1-isopropyl-2-methylpiperazine dihydrochloride. PROPERTIES: This isopropyl- and methyl-substituted piperazine salt has molecular formula C9H18N2 {2HCl. It appears as a white crystalline powder. The (R)-1-isopropyl-2-methylpiperazine dihydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 180-185 C (with decomposition), and it has a molecular weight of approximately 186.12 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The dihydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The (R)-1-isopropyl-2-methylpiperazine dihydrochloride serves as a valuable intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the piperazine ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The isopropyl and methyl groups enhance metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of bioconjugates for drug delivery systems where the amine groups react with targeting moieties, as described in pharmaceutical sciences journals. The amine groups can be further functionalized through acylation or sulfonamidation reactions to produce various derivatives for chemical research applications.
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