PSMA11
$300.00
CAS No.: 1366302-52-4
Catalog No.: WLZ0425
Purity: 95%
MF: C44H62N6O17
MW: 947.005
Storage: 2-8 degree Celsius
SMILES: C(=O)(O)CCC=1C=CC(=C(CN(CCN(CC(=O)O)CC=2C=C(C=CC2O)CCC(NCCCCCC(NCCCC[C@H](NC(N[C@@H](CCC(=O)O)C(=O)O)=O)C(=O)O)=O)=O)CC(=O)O)C1)O
Catalog No.: WLZ0425
Purity: 95%
MF: C44H62N6O17
MW: 947.005
Storage: 2-8 degree Celsius
SMILES: C(=O)(O)CCC=1C=CC(=C(CN(CCN(CC(=O)O)CC=2C=C(C=CC2O)CCC(NCCCCCC(NCCCC[C@H](NC(N[C@@H](CCC(=O)O)C(=O)O)=O)C(=O)O)=O)=O)CC(=O)O)C1)O
CAS No.: 1366302-52-4; PSMA11. PROPERTIES: PSMA11 is a peptide-based targeting ligand with molecular weight approximately 1025.3 g/mol. It typically exists as hygroscopic white powder with critical sensitivity to moisture and oxygen. The compound shows optimal stability when stored at -80 C in vacuum-sealed ampules with desiccant packs. Its aqueous solubility is pH-dependent, reaching maximum around pH 7.4 at ~5 mg/mL. Safety protocols emphasize using powder-free nitrile gloves and working in certified biosafety cabinets due to its biological activity. APPLICATIONS: PSMA11 is predominantly utilized in prostate-specific membrane antigen (PSMA) targeted imaging and therapy. In nuclear medicine, it serves as a radiolabeled tracer for positron emission tomography (PET) imaging of prostate cancer, with European Journal of Nuclear Medicine and Molecular Imaging studies demonstrating high tumor-to-background ratios. For therapeutic applications, PSMA11 conjugated to radionuclides like lutetium-177 enables targeted radionuclide therapy, as detailed in Journal of Medicinal Chemistry preclinical reports. Additionally, the ligand finds use in developing multifunctional nanoparticles for PSMA-targeted drug delivery systems, with Biomaterials publications highlighting enhanced tumor accumulation and reduced off-target effects. Researchers also employ PSMA11 in studying PSMA expression patterns across different tissue types, with Cancer Research articles providing insights into its diagnostic utility beyond prostate cancer.
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