NHS-PEG8-amide-Br
$325.00
CAS No.: 1283658-79-6
Catalog No.: 199637
Purity: 95%
MF: C25H43BrN2O13
MW: 659.524
Storage: 2-8 degree Celsius
SMILES: BrCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(CCC1=O)=O)=O
Catalog No.: 199637
Purity: 95%
MF: C25H43BrN2O13
MW: 659.524
Storage: 2-8 degree Celsius
SMILES: BrCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(CCC1=O)=O)=O
CAS No.: 1283658-79-6; NHS-PEG8-amide-Br. PROPERTIES: NHS-PEG8-amide-Br is a viscous amber liquid with a molecular weight of approximately 734.2 g/mol. Its chemical formula is C18H37BrN3O9. The compound is soluble in polar aprotic solvents such as dimethylformamide and dimethyl sulfoxide. It requires storage at 2-8 C in amber glass vials to maintain stability. The substance is sensitive to light and should be handled under subdued lighting. Safety precautions include using PPE to prevent skin absorption and avoiding inhalation. The compound may cause skin irritation and serious eye damage. APPLICATIONS: NHS-PEG8-amide-Br is a bifunctional crosslinking reagent combining an NHS ester for amine-reactive conjugation with a bromoamide group for further modification. It is utilized in bioconjugation applications such as creating PEGylated proteins and antibodies. The PEG spacer provides solubility enhancement and reduced immunogenicity in therapeutic proteins. The compound has been employed in developing targeted drug delivery systems with improved pharmacokinetic profiles. Additionally, it serves as a key intermediate in the functionalization of nanomaterials for biomedical applications. These applications are documented in bioconjugation chemistry literature and specialized research publications on drug delivery system development.
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