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CAS NO.: 3340-78-1; 2-Phenyl-1,2,3,4-tetrahydroisoquinoline. PROPERTIES: This tetrahydroisoquinoline is a colorless to light yellow liquid with a boiling point of ~280 C285 C. It is soluble in organic solvents like benzene or ethanol and stable under normal conditions. Store in a cool, sealed container away from light. As an aromatic amine, it may cause skin irritation, so use gloves during handling. APPLICATIONS: In organic synthesis and drug discovery, this compound serves as a key intermediate for constructing isoquinoline-based alkaloids or pharmaceuticals. The phenyl and tetrahydroisoquinoline moieties are found in various bioactive molecules, such as dopamine receptor agonists or opioid antagonists. It is used in cyclization reactions or as a starting material for chiral resolution studies. This application is described in alkaloid chemistry and medicinal chemistry literature.