![(S)-N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/t/q/tqp1072_5.jpg)
N-5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl-N'-propylsulfamide
$200.00
CAS No.: 1393813-43-8
Catalog No.: 197262
Purity: 95%
MF: C15H19BrN4O4S
MW: 431.312
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=C(C=C1)C=1C(=NC=NC1OCCO)NS(=O)(=O)NCCC
Catalog No.: 197262
Purity: 95%
MF: C15H19BrN4O4S
MW: 431.312
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=C(C=C1)C=1C(=NC=NC1OCCO)NS(=O)(=O)NCCC
N-5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl-N'-propylsulfamide; CAS No.: 1393813-43-8; N-5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl-N'-propylsulfamide. PROPERTIES: This bromo-hydroxyethoxy-substituted pyrimidine sulfamide features molecular formula C??H??BrN?O?S with molecular weight 407.34 g/mol. It generally appears as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 120-125 C. Exhibits IR absorption for amide (~1650 cm??) and hydroxyl groups (~3300 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a bromo-hydroxyethoxy-substituted pyrimidine sulfamide, N-5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl-N'-propylsulfamide is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the pyrimidine and sulfamide groups provide valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its hydroxyl and sulfamide functionalities enable conjugation to biomolecules via oxime formation and reductive amination (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the bromo substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
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