methyl 4-(difluoromethoxy)-3-hydroxybenzoate
$300.00
CAS No.: 1159429-52-3
Catalog No.: LT0228
Purity: 95%
MF: C9H8F2O4
MW: 218.155
Storage: 2-8 degree Celsius
SMILES: FC(OC1=C(C=C(C(=O)OC)C=C1)O)F
Catalog No.: LT0228
Purity: 95%
MF: C9H8F2O4
MW: 218.155
Storage: 2-8 degree Celsius
SMILES: FC(OC1=C(C=C(C(=O)OC)C=C1)O)F
CAS NO.: 1159429-52-3;methyl 4-(difluoromethoxy)-3-hydroxybenzoate. PROPERTIES: This difluoromethoxy benzoate presents as a white crystalline solid with a molecular weight of approximately 212.1 g/mol. The methyl 4-(difluoromethoxy)-3-hydroxybenzoate combines a difluoromethoxy group with a hydroxybenzoate ester. It exhibits limited aqueous solubility until pH < 4 but dissolves well in DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed ester hydrolysis and base-promoted decarboxylation, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The methyl 4-(difluoromethoxy)-3-hydroxybenzoate serves as a key intermediate in the synthesis of various pharmaceuticals. Its difluoromethoxy group provides enhanced metabolic resistance compared to parent methoxy analogs. Research teams utilize this compound as a starting material for creating beta-blockers and calcium channel antagonists. The hydroxybenzoate ester undergoes reduction to form secondary alcohols for further functionalization. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity and fluorescent probes for bioimaging applications.
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