Ethyl 2-(piperidin-3-ylidene)acetate; CAS No.: 1358679-89-6; Specializing in Small molecules synthesis, we provide piperidinylidene acetates for DPP-4 inhibition. The Z-configured exocyclic double bond and ethyl ester enable sitagliptin analog synthesis. Our Horner-Wadsworth-Emmons reaction achieves precise stereocontrol. This intermediate supports development of antidiabetic agents with improved enzymatic stability.