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CAS NO.: 609-13-2; Ethyl 2-bromo-3-oxobutanoate. PROPERTIES: This -keto ester is a colorless to pale yellow liquid with a boiling point of ~110 C112 C at 15 mmHg. It is soluble in organic solvents but hydrolyzes in water over time. Store in a cool, sealed container away from moisture and bases. As a brominated compound, it may be a skin irritant, so handle with gloves and proper ventilation. APPLICATIONS: In organic synthesis, this compound is used in condensation reactions (e.g., Knoevenagel or Michael additions) due to its reactive -keto carbonyl group. The bromo substituent allows for nucleophilic substitution, making it useful for introducing alkyl groups. It serves as an intermediate in synthesizing pharmaceuticals, such as antifungal or antibacterial agents, and in preparing heterocyclic compounds like pyridines or furans. This utility is described in synthetic organic chemistry protocols and pharmaceutical intermediate literature.