Daraxonrasib (RMC-6236)
$400.00
CAS No.: 2765081-21-6
Catalog No.: 199986
Purity: 98%
MF: C44H58N8O5S
MW: 811.06
Storage: 2-8 degree Celsius
SMILES: C[C@H](OC)C(N=CC(N1CCN(C)CC1)=C2)=[C@@]2[C@](N3CC)=C(CC(C)(C)COC([C@H]4NN(C([C@@H](NC([C@H]5C[C@@H]5C)=O)CC6=NC7=CS6)=O)CCC4)=O)C8=C3C=CC7=C8
Catalog No.: 199986
Purity: 98%
MF: C44H58N8O5S
MW: 811.06
Storage: 2-8 degree Celsius
SMILES: C[C@H](OC)C(N=CC(N1CCN(C)CC1)=C2)=[C@@]2[C@](N3CC)=C(CC(C)(C)COC([C@H]4NN(C([C@@H](NC([C@H]5C[C@@H]5C)=O)CC6=NC7=CS6)=O)CCC4)=O)C8=C3C=CC7=C8
For R&D use only. Not for human or animal use.
Daraxonrasib (RMC-6236) CAS No.: 2765081-21-6 is an orally active, non-covalent RAS (ON) inhibitor. Daraxonrasib disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. Daraxonrasib inhibits pERK. Daraxonrasib has anti-tumor activity against KRAS mutant tumors.
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