RMC-7977
$480.00
CAS No.: 2765082-12-8
Catalog No.: 200966
Purity: 98%
MF: C47H60N8O6S
MW: 865.09
Storage: 2-8 degree Celsius
SMILES: O=C(N1CCC[C@@H]2N1)[C@@H](NC([C@H]3[C@H]4[C@@H]3COC4)=O)CC5=NC(C6=CC7=C(C=C6)N(CC)[C@]([C@]8=C([C@H](C)OC)N=CC(N9CCN(C%10CC%10)CC9)=C8)=C7CC(C)(C)COC2=O)=CS5
Catalog No.: 200966
Purity: 98%
MF: C47H60N8O6S
MW: 865.09
Storage: 2-8 degree Celsius
SMILES: O=C(N1CCC[C@@H]2N1)[C@@H](NC([C@H]3[C@H]4[C@@H]3COC4)=O)CC5=NC(C6=CC7=C(C=C6)N(CC)[C@]([C@]8=C([C@H](C)OC)N=CC(N9CCN(C%10CC%10)CC9)=C8)=C7CC(C)(C)COC2=O)=CS5
For R&D use only. Not for human or animal use.
RMC-7977 CAS No.: 2765082-12-8 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (Kd = 195 nM) and KRAS (G12V) (Kd = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS G12C cancer models, and demonstrates good tolerability across various RAS cancer models.
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