Daraxonrasib (RMC-6236)
$300.00
CAS No.: 2765081-21-6
Catalog No.: 199986
Purity: 98%
MF: C44H58N8O5S
MW: 811.05
Storage: 2-8 degree Celsius,Store in a light-proof and sealed container
SMILES: CC(COC([C@H]1NN(C([C@H](CC2=NC3=CS2)NC([C@H]4C[C@@H]4C)=O)=O)CCC1)=O)(C)CC5=[C@@](N(CC)C6=C5C=C3C=C6)[C@@]7=C([C@H](C)OC)N=CC(N8CCN(C)CC8)=C7
Catalog No.: 199986
Purity: 98%
MF: C44H58N8O5S
MW: 811.05
Storage: 2-8 degree Celsius,Store in a light-proof and sealed container
SMILES: CC(COC([C@H]1NN(C([C@H](CC2=NC3=CS2)NC([C@H]4C[C@@H]4C)=O)=O)CCC1)=O)(C)CC5=[C@@](N(CC)C6=C5C=C3C=C6)[C@@]7=C([C@H](C)OC)N=CC(N8CCN(C)CC8)=C7
For R&D use only. Not for human or veterinary use.
Daraxonrasib (RMC-6236) CAS No.: 2765081-21-6 is an orally active, non-covalent RAS (ON) inhibitor. Daraxonrasib disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. Daraxonrasib inhibits pERK. Daraxonrasib has anti-tumor activity against KRAS mutant tumors.
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