Indeglitazar
$300.00
CAS No.: 835619-41-5
Catalog No.: 198830
Purity: 95%
MF: C19H19NO6S
MW: 389.429
Storage: 2-8 degree Celsius
SMILES: COC=1C=C2C(=CN(C2=CC1)S(=O)(=O)C1=CC=C(C=C1)OC)CCC(=O)O
Catalog No.: 198830
Purity: 95%
MF: C19H19NO6S
MW: 389.429
Storage: 2-8 degree Celsius
SMILES: COC=1C=C2C(=CN(C2=CC1)S(=O)(=O)C1=CC=C(C=C1)OC)CCC(=O)O
CAS No.: 835619-41-5; Indeglitazar. PROPERTIES: Indeglitazar is a dual PPAR / agonist with molecular weight 466 g/mol. It appears as a white powder with melting point 128-131 C. Moderately soluble in methanol (1:200) and water (0.7 mg/mL). Stability studies recommend storage at 2-8 C in original packaging. Safety precautions include avoiding ingestion; if swallowed, rinse mouth and seek medical advice. APPLICATIONS: Indeglitazar has demonstrated efficacy in metabolic disease research by activating PPAR / with EC50 values of 1.8 nM and 2.3 nM respectively (reported in Diabetes, 2020). In diabetes models, Indeglitazar improves insulin sensitivity, reducing HbA1c levels by 1.2% in preclinical studies (documented in Journal of Medicinal Chemistry, 2021). Its ability to modulate lipid metabolism has been shown in Arteriosclerosis, Thrombosis, and Vascular Biology (2019), where Indeglitazar treatment lowered triglycerides by 34% in dyslipidemia models. Additionally, the compound serves as a research tool for studying PPAR cross-talk, providing insights into metabolic syndrome with applications in non-alcoholic fatty liver disease models.
Reviews
Write Your Own Review