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tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate
$350.00
CAS No.: 1319716-42-1
Catalog No.: 197683
Purity: 95%
MF: C13H21NO3
MW: 239.315
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC2(CC1)CC(CC2)=O
Catalog No.: 197683
Purity: 95%
MF: C13H21NO3
MW: 239.315
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC2(CC1)CC(CC2)=O
tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate; CAS No.: 1319716-42-1;tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate. PROPERTIES: tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate is a protected spirocyclic amide with a molecular weight of 241.30 g/mol. This white crystalline solid has a melting point between 145-148 C. The molecule features a spiro[4.4]nonane ring system with an azasubstitution at position 2, a ketone group at position 7, and a tert-butyl carbamate protecting group at position 2. It demonstrates limited solubility in common organic solvents such as ethyl acetate and methanol but is sparingly soluble in water. Proper storage requires keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the carbamate group's potential to release isocyanate under acidic conditions and the ketone group's moderate toxicity. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily functions as a synthetic intermediate in the production of cardiovascular and central nervous system medications, where the spirocyclic scaffold provides essential binding affinity to target enzymes. In pharmaceutical development, it has been utilized in creating angiotensin receptor blockers and has shown promise in developing monoamine oxidase inhibitors for treating neurological disorders. The oxospiroazaspiro nonane structure has also garnered interest in materials science for developing fluorescent probes, leveraging the electron-deficient ketone group to tune optical properties. These applications are supported by research published in the European Journal of Medicinal Chemistry and Dyes and Pigments.
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