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tert-butyl 4-hydroxy-8-azaspiro[4.5]decane-8-carboxylate
$550.00
CAS No.: 1357352-29-4
Catalog No.: 197685
Purity: 95%
MF: C14H25NO3
MW: 255.358
Storage: 2-8 degree Celsius
SMILES: OC1CCCC12CCN(CC2)C(=O)OC(C)(C)C
Catalog No.: 197685
Purity: 95%
MF: C14H25NO3
MW: 255.358
Storage: 2-8 degree Celsius
SMILES: OC1CCCC12CCN(CC2)C(=O)OC(C)(C)C
tert-butyl 4-hydroxy-8-azaspiro[4.5]decane-8-carboxylate; CAS No.: 1357352-29-4;tert-butyl 4-hydroxy-8-azaspiro[4.5]decane-8-carboxylate. PROPERTIES: tert-butyl 4-hydroxy-8-azaspiro[4.5]decane-8-carboxylate is a protected spirocyclic amine with a molecular weight of 263.35 g/mol. This white crystalline solid has a melting point between 135-138 C. The molecule features a spiro[4.5]decane ring system with an azasubstitution at position 8, a hydroxyl group at position 4, and a tert-butyl carbamate protecting group at position 8. It demonstrates limited solubility in common organic solvents such as ethyl acetate and methanol but is sparingly soluble in water. Proper storage involves keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the carbamate group's potential to release isocyanate under acidic conditions and the hydroxyl group's potential to form hydrogen bonds. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily serves as a building block in the synthesis of agrochemicals and pharmaceuticals, where the spirocyclic scaffold provides structural diversity for receptor interactions. In medicinal chemistry, it has been employed in developing antifungal agents targeting plant pathogens and has shown utility in creating herbicides with selective activity against broadleaf weeds. The hydroxyspiroazaspiro decane structure has also been explored in materials science for developing chiral ligands in asymmetric catalysis, leveraging the hydroxyl group's stereoelectronic effects. These applications are documented in publications from the Journal of Agricultural and Food Chemistry and the Journal of Catalysis.
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