tert-butyl 4-ethynyl-4-fluoropiperidine-1-carboxylate
$450.00
CAS No.: 191327-86-3
Catalog No.: 195617
Purity: 95%
MF: C12H18FNO2
MW: 227.279
Storage: 2-8 degree Celsius
SMILES: C(#C)C1(CCN(CC1)C(=O)OC(C)(C)C)F
Catalog No.: 195617
Purity: 95%
MF: C12H18FNO2
MW: 227.279
Storage: 2-8 degree Celsius
SMILES: C(#C)C1(CCN(CC1)C(=O)OC(C)(C)C)F
tert-butyl 4-ethynyl-4-fluoropiperidine-1-carboxylate; CAS No.: 191327-86-3; tert-butyl 4-ethynyl-4-fluoropiperidine-1-carboxylate. PROPERTIES: tert-butyl 4-ethynyl-4-fluoropiperidine-1-carboxylate is a fluorinated piperidine derivative with a molecular weight of approximately 239.2 g/mol. This compound typically exists as a colorless oil with moderate viscosity and demonstrates good solubility in common organic solvents. It is sensitive to both light and moisture, necessitating storage in amber glass containers under anhydrous conditions at temperatures below 10 C. Special handling precautions include avoiding exposure to strong acids and bases, as the ethynyl group may undergo addition reactions. The compound presents moderate acute toxicity via inhalation routes. APPLICATIONS: tert-butyl 4-ethynyl-4-fluoropiperidine-1-carboxylate functions as a key intermediate in click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloadditions. The ethynyl group provides a versatile handle for forming triazole linkages, which are common pharmacophores in drug discovery. In pharmaceutical research, this compound has been employed in the development of kinase inhibitors where the fluorine atom contributes to enzyme binding affinity (source: Journal of Medicinal Chemistry). Additionally, its application extends to the synthesis of PET imaging agents for neuroscience research, where the ethynyl group facilitates radiolabeling (source: Nuclear Medicine and Biology). The compound's utility in bioconjugation chemistry further enhances its application in the development of targeted therapeutics (source: Bioconjugate Chemistry).
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