tert-butyl 4-bromo-3-methylpiperidine-1-carboxylate
$400.00
CAS No.: 1281712-14-8
Catalog No.: 195614
Purity: 95%
MF: C11H20BrNO2
MW: 278.19
Storage: 2-8 degree Celsius
SMILES: BrC1C(CN(CC1)C(=O)OC(C)(C)C)C
Catalog No.: 195614
Purity: 95%
MF: C11H20BrNO2
MW: 278.19
Storage: 2-8 degree Celsius
SMILES: BrC1C(CN(CC1)C(=O)OC(C)(C)C)C
tert-butyl 4-bromo-3-methylpiperidine-1-carboxylate; CAS No.: 1281712-14-8; tert-butyl 4-bromo-3-methylpiperidine-1-carboxylate. PROPERTIES: tert-butyl 4-bromo-3-methylpiperidine-1-carboxylate is a brominated piperidine derivative with a molecular weight of approximately 284.2 g/mol. This compound typically appears as a colorless to pale yellow oil with moderate solubility in organic solvents. It is sensitive to both light and moisture, necessitating storage in amber glass containers under anhydrous conditions at temperatures below 10 C. Special handling precautions include avoiding exposure to strong bases, as the bromo group may undergo elimination reactions. The compound presents moderate acute toxicity via dermal exposure routes. APPLICATIONS: tert-butyl 4-bromo-3-methylpiperidine-1-carboxylate functions as a key intermediate in Suzuki-Miyaura cross-coupling reactions. The bromo group provides a versatile handle for forming carbon-carbon bonds with various aryl and vinyl boronates. In pharmaceutical research, this compound has been employed in the synthesis of kinase inhibitors where the piperidine ring contributes to enzyme binding (source: Journal of Medicinal Chemistry). Additionally, its application extends to the preparation of PET imaging agents for oncology research, where the bromo group facilitates radiolabeling (source: Nuclear Medicine and Biology). The compound's utility in bioconjugation chemistry further enhances its application in the development of targeted therapeutics (source: Bioconjugate Chemistry).
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