methyl 3-bromo-2-nitrobenzoate
$450.00
CAS No.: 104670-71-5
Catalog No.: 195772
Purity: 95%
MF: C8H6BrNO4
MW: 260.043
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=C(C(=O)OC)C=CC1)[N+](=O)[O-]
Catalog No.: 195772
Purity: 95%
MF: C8H6BrNO4
MW: 260.043
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=C(C(=O)OC)C=CC1)[N+](=O)[O-]
For R&D use only. Not for human or animal use.
methyl 3-bromo-2-nitrobenzoate; CAS No.: 104670-71-5; methyl 3-bromo-2-nitrobenzoate. PROPERTIES: Methyl 3-bromo-2-nitrobenzoate has molecular formula C8H6BrNO3, corresponding to a molecular weight of 253.04 g/mol. It appears as a white crystalline solid with a melting point between 15-18 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong reducing agents. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) away from strong bases. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 2.1 and exhibits limited aqueous solubility. APPLICATIONS: This methyl 3-bromo-2-nitrobenzoate is extensively used in the synthesis of antimicrobial agents. Its bromo-nitrobenzoate structure provides a platform for developing antibacterial agents targeting bacterial DNA gyrase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against Gram-negative pathogens. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The bromo and nitro groups provide electron-withdrawing effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The nitro group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Chemical Communications.
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