1-phenyl-5-(pyrrolidin-3-yl)-1H-1,2,4-triazole
$400.00
CAS No.: 1785451-89-9
Catalog No.: LT0007
Purity: 95%
MF: C12H14N4
MW: 214.272
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)N1N=CN=C1C1CNCC1
Catalog No.: LT0007
Purity: 95%
MF: C12H14N4
MW: 214.272
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)N1N=CN=C1C1CNCC1
CAS NO.: 1785451-89-9;1-phenyl-5-(pyrrolidin-3-yl)-1H-1,2,4-triazole. PROPERTIES: This triazole derivative presents as a white crystalline solid with a molecular weight of approximately 247.3 g/mol. The 1-phenyl-5-(pyrrolidin-3-yl)-1H-1,2,4-triazole combines a phenyl group with a pyrrolidine substituent on a triazole ring. It exhibits moderate solubility in water and good dissolution in lower alcohols and DMSO. Stability characterization reveals vulnerability to oxidation and base-catalyzed hydrolysis of the triazole ring, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 1-phenyl-5-(pyrrolidin-3-yl)-1H-1,2,4-triazole serves as a key intermediate in the synthesis of various pharmaceuticals. Its triazole ring provides opportunities for click chemistry reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and muscarinic receptor modulators. The pyrrolidine group undergoes oxidation to form more complex ring systems. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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