4-(4-chlorophenyl)tetrahydro-2H-thiopyran-4-ol
$400.00
CAS No.: 853886-99-4
Catalog No.: LT0016
Purity: 95%
MF: C11H13ClOS
MW: 228.744
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)C1(CCSCC1)O
Catalog No.: LT0016
Purity: 95%
MF: C11H13ClOS
MW: 228.744
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)C1(CCSCC1)O
CAS NO.: 853886-99-4;4-(4-chlorophenyl)tetrahydro-2H-thiopyran-4-ol. PROPERTIES: This chlorinated sulfur-containing alcohol presents as a colorless liquid with a molecular weight of approximately 235.7 g/mol. The 4-(4-chlorophenyl)tetrahydro-2H-thiopyran-4-ol combines a chlorophenyl group with a thiopyran ring and hydroxyl functionality. It exhibits limited aqueous solubility but good dissolution in ethyl acetate and methanol. Stability characterization reveals sensitivity to oxidation and base-catalyzed elimination of the hydroxyl group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause mild irritation requiring thorough washing. Inhalation may induce respiratory tract irritation; treatment includes fresh air and medical evaluation. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 4-(4-chlorophenyl)tetrahydro-2H-thiopyran-4-ol serves as a key intermediate in the synthesis of various pharmaceuticals. Its thiopyran hydroxyl group provides opportunities for oxidation to ketones or alkylation for further functionalization. Research teams utilize this compound as a starting material for creating beta-blockers and muscarinic receptor modulators. The chlorophenyl group enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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